Darunavir Intermediate CAS 102123-74-0 Purity ≥98.0% (HPLC)

Short Description:

Chemical Name: (3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone 

CAS: 102123-74-0

Appearance: White to Off-White Crystalline Powder

Purity: ≥98.0% (HPLC) 

Intermediate of Darunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor Antiretroviral

High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name (3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone
Synonyms (S)-tert-Butyl (4-Chloro-3-oxo-1-Phenylbutan-2-yl)Carbamate
CAS Number 102123-74-0
CAT Number RF-PI287
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C15H20ClNO3
Molecular Weight 297.78
Shipping Condition Shipped Under Ambient Temperature
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Off-White Crystalline Powder
Identification (HPLC) The Identification is Confirmed by HPLC
Loss on Drying ≤0.50%
Moisture (K.F) ≤0.50%
Melting Point 104.0~107.0℃
Residue on Ignition ≤0.20%
Specific Rotation -48.0° ~ -42.0°
Purity / Analysis Method ≥98.0% (HPLC)
Test Standard Enterprise Standard
Usage Intermediate of Darunavir (CAS 206361-99-1) HIV-1 Protease Inhibitor 

Package & Storage:

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone (CAS: 102123-74-0) with high quality, an intermediate typically in the synthesis of Darunavir (CAS 206361-99-1) and Darunavir Ethanolate (CAS 635728-49-3).

Darunavir (CAS 206361-99-1) (TMC114) is a second generation nonpeptidic HIV protease inhibitor, used to treat AIDS and HIV infection, structurally similar to amprenavir. Antiviral. Due to the emergence of Antiviral drug resistance when used alone, it is administered in combination with other Anti-HIV agents. Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. 

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